Differences in Cardiovascular Disease Risk Factors Associated With Maximum and Mean Carotid Intima-Media Thickness Among Hemodialysis Patients

Authors

  • Amir Ahmad Nassiri Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Monirsadat Hakemi Author
  • Reza Asadzadeh Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Ali Mohammad Faizei Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Sudabeh Alatab Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Reza Miri Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Mehdi Yaseri Tehran University of Medical Sciences, Tehran, Iran Author

Abstract

Introduction. Carotid intima-media thickness (CIMT) could be used as a surrogate marker of atherosclerosis in hemodialysis patients. Since different mechanisms are involved in the atheroma formation and arterial wall thickness, we assessed the relationship between the maximum and the mean CIMT with different cardiovascular risk factors in dialysis patients. Materials and Methods.  The mean and the maximum CIMT were measured using a B-mode ultrasonography in 75 hemodialysis patients, and the correlation between CIMT and cardiovascular risk factors were assessed.

Results. The mean and maximum CIMT measurements were 0.5 mm (range, 0.2 mm to 1 mm) and 3.4 mm (1.4 mm to 5.6 mm), respectively. Among all the studied variables, age (P = .04, r = 0.238), HS-CRP (P = .01, r = 0.284), mean arterial blood pressure (P = .003, r = 0.343), and DM (P = .02) had significant correlations with the mean CIMT, while only age (P = .02, r = 0.473) and serum creatinine levels (P = .02, r = -0.493) were significantly associated with the maximum CIMT. A positive nonsignificant correlation was observed between the mean and maximum CIMT values (P = .08, R2 linear = 0.214).  

Conclusions. These findings suggest that in dialysis patients, effects of cardiovascular risk factors on the mean and maximum CIMT might be different. Further studies are recommended to evaluate the prediction impact of each risk factor in end-stage renal disease patients compared with otherwise healthy individuals.

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Published

2012-05-02

Issue

Section

ORIGINAL | Dialysis

How to Cite

Differences in Cardiovascular Disease Risk Factors Associated With Maximum and Mean Carotid Intima-Media Thickness Among Hemodialysis Patients. (2012). Iranian Journal of Kidney Diseases, 6(3), 203-208. https://ijkd.org/index.php/ijkd/article/view/664

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