Impact of Circulating SARS-CoV-2 Mutant G614 on the COVID-19 Pandemic


  • Doryaneh Ahmadpour Institute for Biomedicine, Sahlgrenska Academy, Centre for Ageing and Health-AgeCap, University of Gothenburg, Gothenburg, Sweden Author
  • Pedram Ahmadpoor Department of Nephrology, Dialysis and Apheresis, Nîmes University Hospital Center, Nîmes, France Author
  • Lionel Rostaing Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble?Alpes, Grenoble, France Author


Coronavirus family has caused several human illnesses, the latest caused by SARS-CoV-2, has led to COVID-19 pandemic posing serious threat to global health. A SARS-CoV-2 variant encoding a D614G mutation in the viral spike (S) protein has now become the most prevalent form of the virus worldwide, suggesting a fitness advantage for the mutant. The G614 variant is associated with higher upper respiratory tract viral load, higher infectivity, increased total S protein incorporation into the virion, reduced S1 shedding and a conformational change leading to a more ACE2- binding and fusion- competent state. However, it does not seem to be correlated to increased disease severity or escape neutralizing antibodies.


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How to Cite

Impact of Circulating SARS-CoV-2 Mutant G614 on the COVID-19 Pandemic. (2020). Iranian Journal of Kidney Diseases, 14(5), 331-334.

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