Vol. 5 No. 2 (2011): March
About the cover:Action of aldosterone in hypovolemia. Elevated level of angiotensin II in the setting of hypovolemia induces WNK-4 phosphorylation, which in turn phosphorylates SPAK (serine threonine proline-alanine rich kinase). Phosphorylated SPAK activates Na/Cl cotransporter. On the other hand, an unknown factor phosphorylates LWNK-1 which downregulates ROMK channel. Therefore, potassium secretion is inhibited despite elevated aldosterone level-Role of aldosterone in endothelial sodium channel (ENac) trafficking. Aldosterone induces serum and glucocorticoid-regulated kinase 1 (SGK1), 14-3-3, Usp2-
45, glucocorticoid-induced leucine zipper and K-ras. K-ras downregulates ENac via Raf pathway. On the other hand, it upregulates ENac by phosphorylating SGK1. Serum and glucocorticoid-regulated kinase 1, ubiquitin-specific protease (Usp2-45), and 14-3-3 deubiquitylate ENac. neural precursor cell-expressed developmentally downregulated (gene 4) protein (Nedd4-2) ubiquitylates ENac.
