Platelet-to-Lymphocyte Ratio is Associated with the Mortality in Peritoneal Dialysis Patients

Authors

  • Siyi Liu Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China Author
  • Mei Yang Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China Author
  • Qing Zhao Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China Author
  • Li Zhang Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China Author
  • Qinkai Chen Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China Author
  • Yu Wang Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China Author

Abstract

Introduction. Platelet-to-lymphocyte ratio (PLR) is widely used as an inflammatory marker and is associated with poor prognosis in some diseases, such as cardiovascular diseases and malignancies. However, the association between the PLR and all-cause mortality in peritoneal dialysis (PD) patients is unclear. Methods. A total of 939 patients were enrolled. The X-tile program was performed to calculate the optimal cut-off values for the PLR, and the patients were divided into three groups according to the cut-off values: a low PLR group (< 108.33), medium PLR group (108.33 to 257.50), and high PLR group (> 257.50). Multivariate analysis was performed to assess the prognostic value of PLR. The primary end point was all-cause mortality. Results. Of the 939 patients, the mean age was 49.9 years, and 57% of the patients were male. During a median follow-up of 27.5 months (interquartile range, 13.6-41.6 months), 221 (23.5%) died, in whom 114 (51.6%) deaths were attributed to cardiovascular mortality. Patients in the high PLR group had a higher mortality rate than patients in the low PLR group (log rank = 13.75, P < .001). The 1-year and 3-year overall survival rates were 88.9% and 71.7% for patients in the high PLR group compared with 98.6% and 86.2% for patients in the low PLR group, respectively. Similarly, multivariate Cox regression analysis showed that the mortality rate was higher in the high PLR group than in the low PLR group (HR = 1.64, 95% CI: 1.02 to 2.63, P < .05). Conclusion. An increased PLR value was independently associated with all-cause mortality in PD patients.

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Author Biographies

  • Siyi Liu, Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China
    Nephrology
  • Mei Yang, Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China
    Nephrology
  • Qing Zhao, Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China
    Nephrology
  • Li Zhang, Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China
    Nephrology
  • Qinkai Chen, Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China
    Nephrology
  • Yu Wang, Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China

    Nephrology

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Published

2021-05-15

Issue

Section

ORIGINAL | Dialysis

How to Cite

Platelet-to-Lymphocyte Ratio is Associated with the Mortality in Peritoneal Dialysis Patients. (2021). Iranian Journal of Kidney Diseases, 15(3), 206-212. https://ijkd.org/index.php/ijkd/article/view/5765

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