Lack of Association Between TNF-alpha rs1800629 (-308G > A) Polymorphism and Nephrotic Syndrome

Authors

  • Simin Sadeghi-Bojd Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran Author
  • Mohammad Hashemi Genetics of Noncommunicable Disease Research Center, Zahedan University of Medical sciences, Zahedan, Iran Author
  • Mahrokh Firoozi-Jahanigh Department of Pediatrics, School of Medicine, Zahedan University of Medical sciences, Zahedan, Iran Author
  • Maryam Rezaei Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Author
  • Hosna Sarani Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran Author
  • Mohsen Taheri Genetics of Noncommunicable Disease Research Center, Zahedan University of Medical sciences, Zahedan, Iran Author

Abstract

Introduction. Idiopathic Nephrotic Syndrome is a multifactorial disease that accompanying with immune system dysfunction. Cytokines as potent immunomodulators have a key role in pathogenesis of the disease. We aimed to evaluate the association between TNFα -308G > A polymorphism with Idiopathic Nephrotic Syndrome and its effect on the response to steroid therapy. Methods. This case-control study was performed on 168 patients with Nephrotic Syndrome and 153 healthy children. Genotyping of TNF-α rs1800629 (-308G > A) variant was detected by polymerase chain reaction restriction fragment length polymorphism method (PCR-RFLP). Results. The results revealed that there was no significant difference in allele (P > .05, OR = 0.92, 95% CI: 0.59 to 1.43) or genotype (P > .05, OR = 1.00; 95% CI: 0.62 to 1.65) frequency of TNF-α rs1800629 (-308G > A) between childhood cases of nephrotic syndrome and healthy controls. Also no association was found between genotype (P > .05, OR = 2.28; 95% CI: 1.03 to 5.04), and allele frequency (P > .05, OR = 1.93; 95% CI: 0.97 to 3.87) among the SSNS and SRNS groups. Conclusion. Our results did not support any association between the TNF polymorphism and the risk of nephrotic syndrome in a sample of southeast Iranian population.

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Published

2021-03-17

Issue

Section

ORIGINAL | Kidney Diseases

How to Cite

Lack of Association Between TNF-alpha rs1800629 (-308G > A) Polymorphism and Nephrotic Syndrome. (2021). Iranian Journal of Kidney Diseases, 1(2), 95-100. https://ijkd.org/index.php/ijkd/article/view/5597