Massive Proteinuria and Autosomal Dominant Polycystic Kidney Disease: a Rare Coincidence

Authors

  • Shokoufeh Savaj Department of Nephrology, Firoozgar General Hospital, Tehran University of Medical Sciences, Tehran, Iran Author
  • Mahmoud Parvin Department of Pathology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Javad Savoj Author

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) with nephrotic syndrome is a rare coincidence. Among 19 reported cases since 1972, focal glomerulosclerosis is the dominant reported pathology. Here, we report the 6th case of focal segmental glomerulosclerosis with ADPKD. A 29-year-old man with a history of APCDK presented with massive proteinuria. He had a history of concurrent leptospirosis and brucellosis, and trace proteinuria and mild hypertension had been diagnosed 4 years earlier. Urine study showed proteinuria (21 g/d) and hematuria. Kidney biopsy report was compatible with focal and segmental sclerosis. The patient received prednisolone and cyclosporine. After 4 months, proteinuria decreased to 600 mg/d. Patients with ADPKD who show massive proteinuria should undergo kidney biopsy. It is possible that different mutations in these patients could clarify the nature of this coincidence.

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Author Biographies

  • Shokoufeh Savaj, Department of Nephrology, Firoozgar General Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Department of Nephroloy,Firouzgar Hospital
  • Mahmoud Parvin, Department of Pathology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

     

    department of Pathology,Labafinejad Hospital

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Published

2012-01-04

Issue

Section

CASE REPORT | Kidney Diseases

How to Cite

Massive Proteinuria and Autosomal Dominant Polycystic Kidney Disease: a Rare Coincidence. (2012). Iranian Journal of Kidney Diseases, 6(1), 73-76. https://ijkd.org/index.php/ijkd/article/view/533

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