Posttransplant Lymphoproliferative Disorders in Kidney Transplant Recipients: An Iranian Multicenter Experience

Authors

  • Behzad Einollahi Nephrology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Author
  • Mahboob Lessan-Pezeshki Department of Nephrology, Tehran University of Medical Sciences, Tehran, Iran Author
  • Mohammad Hossein Nourbala Nephrology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Author
  • Nasser Simforoosh Department of Kidney Transplant, Shahid Beheshti University (MC), Tehran, Iran Author
  • Vahid Pourfarziani Nephrology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Author
  • Eghlim Nemati Nephrology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Author
  • Mohsen Nafar Department of Kidney Transplant, Shahid Beheshti University (MC), Tehran, Iran Author
  • Abbas Basiri Department of Kidney Transplant, Shahid Beheshti University (MC), Tehran, Iran Author
  • Fatemeh Pour-Reza-Gholi Department of Kidney Transplant, Shahid Beheshti University (MC), Tehran, Iran Author
  • Ahmad Firoozan Department of Kidney Transplant, Shahid Beheshti University (MC), Tehran, Iran Author
  • Mohammad Hassan Ghadiani Nephrology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Author
  • Khadijeh Makhdoomi Department of Nephrology, Urmia University of Medical Sciences, Urmia, Iran Author
  • Ali Ghafari Department of Nephrology, Urmia University of Medical Sciences, Urmia, Iran Author
  • Pedram Ahmadpour Department of Kidney Transplant, Shahid Beheshti University (MC), Tehran, Iran Author
  • Farshid Oliaei Department of Nephrology, Babol University of Medical Sciences, Babol, Iran Author
  • Mohammad Reza Ardalan Department of Nephrology, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Atieh Makhlough Department of Nephrology, Sari University of Medical Sciences, Sari, Iran Author
  • Hamid Reza Samimagham Department of Nephrology, Hormozgan University of Medical Sciences, Bandarabbas, Iran Author
  • Jalal Azmandian Department of Nephrology, Kerman University of Medical Sciences, Kerman, Iran Author
  • Efat Razeghi Department of Nephrology, Tehran University of Medical Sciences, Tehran, Iran Author
  • Heshmatollah Shahbazian Department of Nephrology, Ahwaz University of Medical Sciences, Ahwaz, Iran Author

Abstract

Introduction. Limited data with adequate sample size exist on the development of posttransplant lymphoproliferative disorder (PTLD) in living donor kidney recipients. We conducted a retrospective cohort study on the data of 10 transplant centers to identify the incidence of PTLD in Iran.

Materials and Methods. Data of 9917 kidney transplant recipients who received their kidneys between 1984 and 2008 were reviewed. Fifty-one recipients (0.5%) who developed PTLD were evaluated with a median follow-up of 47.5 months (range, 1 to 211) months.

Results. Patients with PTLD represented 24% of all posttransplant malignancies (51 out of 211 cases). There was no relationship between PTLD and sex (P = .20). There were no statistically significance differences considering the age at transplantation between patients with and without PTLD. The late-onset PTLD (70.6%) occurred more frequently compared to the early form. There was no signification relationship between early-onset and late-onset groups in terms of clinical course and outcome. In patients who received azathioprine, PTLD was more frequent when compared to those who received mycophenolate mofetil (P < .001). The lymph nodes were the predominantly involved site (35.3%), followed by the gastrointestinal tract, brain, kidney allograft, lung, ovary, vertebrae, and palatine. Age at diagnosis and the time from transplantation to diagnosis were comparable for various involvement sites of PTLDs. The overall mortality in this series of patients was 51.0%.

Conclusions. Posttransplant lymphoproliferative disorder is a rare but devastating complication and long-term prognosis can be improved with early recognition and appropriate therapy.

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Published

2009-03-14

Issue

Section

ORIGINAL | Transplantation

How to Cite

Posttransplant Lymphoproliferative Disorders in Kidney Transplant Recipients: An Iranian Multicenter Experience. (2009). Iranian Journal of Kidney Diseases, 2(4), 227-233. https://ijkd.org/index.php/ijkd/article/view/25

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