Mitochondrion and Its Role in Diabetic Nephropathy

Authors

  • Farhad Khoshjou Urology and Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Author
  • Farahnaz Dadras Urology and Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Author

Abstract

Diabetic nephropathy is a major cause of end-stage renal disease throughout the world. Elevated oxidative stress in diabetic patients results from overproduction of reactive oxygen species and decreased efficiency of antioxidant defenses. Moreover, diabetes-associated metabolic disorders impair activities of enzymes of the mitochondrial respiratory chain complex. Therefore, oxidative stress is closely related to mitochondrial dysfunction. This paper reviews studies of mitochondrial dysfunction in diabetic nephropathy.

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Author Biographies

  • Farhad Khoshjou, Urology and Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
    Nephrology ward,assisstant professor
  • Farahnaz Dadras, Urology and Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
    Nephrology ward,assisstant professor

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Published

2014-06-21

Issue

Section

REVIEW | Kidney Diseases

How to Cite

Mitochondrion and Its Role in Diabetic Nephropathy. (2014). Iranian Journal of Kidney Diseases, 8(5), 355-358. https://ijkd.org/index.php/ijkd/article/view/1572