Seroprevalence of Anti-Helicobacter Pylori and Anticytotoxin-associated Gene A Antibodies According to ABO Blood Groups and Rhesus Status Among Hemodialysis Patients

Abstract

Introduction. Correlation between Helicobacter pylori infection and blood group typing has been widely evaluated in both patients and healthy population. However, data addressing this correlation in hemodialysis patients are scarce. The aim of this study was to evaluate the prevalence of anti-Helicobacter pylori and anticytotoxin-associated gene A (anti-Cag A) antibodies and their correlations with ABO blood groups and rhesus blood group status in hemodialysis patients.

Materials and Methods. In a cross-sectional study, serum samples of 151 hemodialysis patients were tested for anti-Helicobacter pylori IgG antibody. Anti-Cag A antibody (IgG antibody) was tested in Helicobacter pylori-positive patients. ABO blood groups typing and rhesus status were tested by hemagglutination test.

Results. Prevalence of anti-Helicobacter pylori and anti-Cag A antibodies in Helicobacter pylori-positive patients were 65.6% (99 of 151) and 25.3% (25 of 99), respectively. Prevalence of anti-Helicobacter pylori and anti-Cag A antibodies were 69.1% and 36.8% in patients with blood group A, 42.3% and 9.1% in blood group B, 75.0 % and zero in blood group AB, 69.4% and 23.3% in blood group O, 59.0% and 30.6% in rhesus-positive status and 89.7% and 11.5% in rhesus-negative status, respectively. There was a significant correlation between the presence of anti-Helicobacter pylori and anti-Cag A antibodies and rhesus status, but no significant relation between ABO blood groups and anti-Cag A antibodies were found.

Conclusions. Rhesus status may have an impact on the presence of anti-Helicobacter pylori and anti-Cag A antibodies. More investigations to address this correlation are necessary.