Sodium-Glucose Cotransporter-2 Inhibitors in Patients with Non-diabetic Chronic Kidney Disease: A Systematic Review

Authors

  • Nakisa Rasaei Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Author
  • Leila Malekmakan Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Author
  • Ghazal Gholamabbas Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Author
  • Mina Mashayekh Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Author
  • Farshad Hadianfard Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Author
  • Mahsa Torabi Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Author

Abstract

Sodium-glucose cotransporter-2 (SGLT2) inhibitors modulate kidney function in diabetic chronic kidney disease trials. Furthermore, recent studies have showed their effect on kidney dysfunction in non-diabetic chronic kidney disease (CKD). Here, we focus on the impact of SGLT2 inhibitors on some renal parameters in nondiabetic CKD by discussing completed and ongoing trials. Different databases and search engines of Web of Science, PubMed, Google Scholar, Scopus, SID, and Magiran were searched until November 2022. We included human studies that evaluated the effect of SGLT2 inhibitors in non-diabetic CKD participants. Two authors independently screened the articles for inclusion, extracted the data, and assessed the quality of the included studies. The primary outcomes were the effect of the SGLT2 inhibitors on proteinuria, GFR and blood pressure. A total of 46 full texts were assessed for eligibility, and further review. After reviewing the full texts, seven eligible articles were entered included in this study. We suggest that SGLT2 inhibitors provide renal protection by modifying predisposing factors in the development of CKD, specifically albuminuria and GFR decrease. Other beneficial effects of these agents on blood pressure and sympathetic nerve activity might be considered as a possible mechanism for improving renal hemodynamics. We believe SGLT2 inhibitors could be considered as an effective add-on therapy in non-diabetic CKD patients.

 

DOI: 10.52547/ijkd.7309

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Published

2023-08-24

Issue

Section

REVIEW | Kidney Diseases

How to Cite

Sodium-Glucose Cotransporter-2 Inhibitors in Patients with Non-diabetic Chronic Kidney Disease: A Systematic Review. (2023). Iranian Journal of Kidney Diseases, 17(4), 175-183. https://ijkd.org/index.php/ijkd/article/view/7309

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