Antibody-mediated Rejection of Kidney Allografts Following COVID-19: A Report of Two Cases

Authors

  • Seyed Amirhossein Fazeli Clinical Research and Development Center at Shahid Modarres Hospital, Department of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Miralireza Takyar Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Mahmoud Parvin Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Abdolreza Haririan Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA Author
  • Amirhesam Alirezaei Clinical Research and Development Center at Shahid Modarres Hospital, Department of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author

Abstract

Increased risk of graft rejection could be the consequence of COVID-19 in kidney transplant recipients (KTRs). We report two cases of kidney transplant (KT) with stable graft function who experienced antibody-mediated rejection (ABMR) following recovery from COVID-19. It seems that reduced immunosuppression during the acute illness, is the main explanation for post-COVID-19 ABMR. However, the inflammatory state associated with COVID-19, as well as direct cytopathic effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can predispose the kidney allograft to rejection. There is no definite guideline for the modification of immunosuppressives during COVID-19 in kidney transplant recipients. However, re-institution of full-dose immunosuppressives soon after recovery from COVID-19 and frequent outpatient follow-up visits are recommended.

 

DOI: 10.52547/ijkd.7176

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Published

2022-11-30

Issue

Vol. 16 No. 6 (2022): November

Section

BRIEF REVIEW | Transplantation

How to Cite

Antibody-mediated Rejection of Kidney Allografts Following COVID-19: A Report of Two Cases. (2022). Iranian Journal of Kidney Diseases, 16(6), 330-336. https://ijkd.org/index.php/ijkd/article/view/7176

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