Effect of Submaximal Aerobic Exercise in Hypoxic Conditions on Proteinuria and Hematuria in Physically Trained Young Men

Authors

  • Mohammad Ali Kohanpour Department of Exercise Physiology, Islamic Azad University, Tehran, Iran Author
  • Suzan Sanavi Clinical Department, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Author
  • Maghsoud Peeri Department of Exercise Physiology, Islamic Azad University, Tehran, Iran Author
  • Amir Hamzeh Zare Department of Exercise Physiology, Shiraz University of Medical Sciences, Shiraz, Iran Author
  • Mona Mirsepasi Department of Exercise Physiology, Islamic Azad University, Tehran, Iran Author

Abstract

Introduction. Exercise-induced proteinuria is predominantly caused by alterations in renal hemodynamics. The present study was conducted to determine the effect of aerobic exercise in hypoxia on proteinuria and hematuria.

Materials and Methods. The study population consisted of 17 physically trained healthy young men. They were asked to attend in 4 sets of 30-minute running sessions, separated by 72-hour resting intervals, to attain 70% of maximal heart rate in normoxia (fraction of inspired oxygen of 0.21) and 3 different levels of hypoxia (lower fraction of inspired oxygen equivalent to the heights of 2750 m, 3250 m, and 3750 m above the sea level). Urine samples were collected before exercise and immediately and 1 hour after each session to measure total protein, albumin, beta2-microglobulin, and erythrocyte count.

Results. Postexercise urinary total protein, albumin, and beta2-microglobulin showed significant increases compared to basline values, while no significant difference was found in urinary total protein between hypoxia and normoxia conditions. However, there was a significant positive correlation between the amount of albuminuria and the height (P = .01), and a significant difference in beta2-microglobulinuria between normoxia and the simulated 2750-m altitude (P = .007), which disappeared at higher elevations. None of the participants developed hematuria.

Conclusions. Aerobic exercise with moderate intensity in trained men might induce mixed proteinuria with glomerular predominance correlated with height, while tubular component loses this relation at altitudes above 2750 m. Further research on the influence of exercise on urinary abnormalities, particularly in different environmental conditions, is recommended.

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Author Biographies

  • Mohammad Ali Kohanpour, Department of Exercise Physiology, Islamic Azad University, Tehran, Iran

    Exercise Physiology

    M.Sc

  • Suzan Sanavi, Clinical Department, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
    Clinical, Clinical fellow Of Nephrology, Internist
  • Maghsoud Peeri, Department of Exercise Physiology, Islamic Azad University, Tehran, Iran
    Exercise Physiology, Ph.D
  • Amir Hamzeh Zare, Department of Exercise Physiology, Shiraz University of Medical Sciences, Shiraz, Iran

    Exercise Physiology

    M.Sc

  • Mona Mirsepasi, Department of Exercise Physiology, Islamic Azad University, Tehran, Iran

    Exercise Physiology

    M.Sc

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Published

2012-05-02

Issue

Section

ORIGINAL | Kidney Diseases

How to Cite

Effect of Submaximal Aerobic Exercise in Hypoxic Conditions on Proteinuria and Hematuria in Physically Trained Young Men. (2012). Iranian Journal of Kidney Diseases, 6(3), 192-197. https://ijkd.org/index.php/ijkd/article/view/665