Relationship Between Thyroid Hormones and Left Ventricular Mass in Peritoneal Dialysis Patients

Authors

  • Fatemeh Musavi Mehdiabadi Department of Nephrology, Kerman University Of Medical Sciences, Kerman, Iran Author
  • Alireza Rashidinejad Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University Of Medical Science, Tehran, Iran Author
  • Amin Mahdavi Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran Author
  • Tania Dehesh Department of Biostatistics and Epidemiology, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran Author

Abstract

Introduction. Non-thyroidal illness is prevalent in patients with advanced stages of chronic kidney disease and could be considered as a risk factor for cardiovascular mortality; this relation is partially explained by malnutrition and the concomitant condition of high inflammation. This study is designed to investigate the relationship between left ventricular mass and thyroid hormone abnormalities and evaluate this relationship after adjustment of inflammatory factors and nutritional status in peritoneal dialysis patients. Methods. A total of 71 patients undergoing maintenance peritoneal dialysis were included. Serum concentration of total and free triiodothyronine (fT3), total and free thyroxine (fT4), and TSH were measured. LV mass index and the structural properties of heart including LVEDD, LVESD, PWD, and EF were assessed by transthoracic echocardiography. The Surrogates of Inflammation, including IL-6, albumin, and hs-CRP were measured. The nutritional status of patients was assessed by one point SGA scoring and biochemical data. The relation between thyroid hormones and echocardiographic variables, inflammatory and nutritional markers was determined. Results. LVMI was significantly higher in the group with lower fT3 levels. Linear regression analyses showed statistically significant univariate association between fT3, tT3, and tT4; and LVMI. In multiple linear regression analysis adjusted for albumin, hs-CRP, IL- 6, and ferritin; only fT3 level had a meaningful negative correlation (P < .05) with LVMI, free T3 level was positively correlated with rGFR (P < .05, c = 0.39) and KT/V (P < .05, c = 0.27). Conclusion. Low fT3 level was negatively and significantly associated with LVML even after adjustments for known risk factors in peritoneal dialysis patients.

Downloads

Download data is not yet available.

Downloads

Published

2020-09-16

Issue

Section

ORIGINAL | Dialysis

How to Cite

Relationship Between Thyroid Hormones and Left Ventricular Mass in Peritoneal Dialysis Patients. (2020). Iranian Journal of Kidney Diseases, 14(5), 380-388. https://ijkd.org/index.php/ijkd/article/view/5158

Most read articles by the same author(s)