Cross-linked Polyelectrolyte and Its Function in Adsorption of Fluid and Excess Nitrogen Waste Products: an Experimental Study on Dialysate Effluent Fluid

Authors

  • Hamid Tayebi Khosroshahi Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Behzad Abedi Department of Medical Bioengineering, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Sabalan Daneshvar Faculty of Electrical and Computer Engineering, University of Tabriz, Tabriz, Iran Author
  • Effat Alizadeh Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Mohammadreza Khalilzadeh Hemodialysis Center, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran Author
  • Yaghoub Abedi Faran Shimi Pharmaceutical Company, Hamadan, Tuyserkan, Iran Author

Abstract

Introduction. One of the most important issues in patients with chronic kidney disease is fluid retention and volume overload accompanied by retention of nitrogenous waste products and some electrolytes. Bowel fluid contains high levels of urea, creatinine, uric acid, and electrolytes, which make it a potential candidate for intestinal excretion of nitrogen wastes and electrolytes. Cross-linked polyelectrolyte (CLP) is a polymer that, given orally, absorbs excess fluid, electrolyte, and nitrogenous waste products.

Materials and Methods. In an experimental study on 30 hemodialysis patients, the effect of CLP on adsorption of fluid, urea, creatinine, uric acid, sodium, and potassium were evaluated. For this purpose, 500 mL of effluent fluid of each patient were collected at the 1st hour of dialysis. The concentrations of the abovementioned products were measured by standard methods. Then the dialysate effluent samples were treated with 6 g of CLP and incubated for 4 hours at 37°C.

Results. Up to 80% of effluent fluid water was adsorbed by CLP. There were significant reductions in urea, creatinine, uric acid, and sodium levels in the remaining effluent fluid (P < .001). In contrast, the amount of potassium increased in the effluent fluid.

Conclusions. Using CLP in addition to functional medical super adsorbents can be a possible adequate substitute for conventional dialysis methods, especially hemodialysis.

Downloads

Download data is not yet available.

Downloads

Published

2017-06-02

Issue

Section

ORIGINAL | Dialysis

How to Cite

Cross-linked Polyelectrolyte and Its Function in Adsorption of Fluid and Excess Nitrogen Waste Products: an Experimental Study on Dialysate Effluent Fluid. (2017). Iranian Journal of Kidney Diseases, 11(4), 294-302. https://ijkd.org/index.php/ijkd/article/view/2996

Most read articles by the same author(s)