Distal Renal Tubular Acidosis and Its Relationship With Hearing Loss in Children: Preliminary Report

Authors

  • Mostafa Sharifian Pediatric Infectious Research Center and Department of Nephrology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Nasrin Esfandiar Pediatric Infectious Research Center and Department of Nephrology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Samira Mazaheri Pediatric Infectious Research Center and Department of Nephrology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Ariana Kariminejad Kariminejad-Najmabadi Pathology-Genetic Center, Tehran, Iran Author
  • Masoumeh Mohkam Pediatric Infectious Research Center and Department of Nephrology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Reza Dalirani Pediatric Infectious Research Center and Department of Nephrology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Rana Esmaili Pediatric Infectious Research Center and Department of Nephrology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Mitra Ahmadi Pediatric Infectious Research Center and Department of Nephrology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Mehrnoush Hassas-Yeganeh Pediatric Infectious Research Center and Department of Nephrology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author

Abstract

Introduction. In autosomal recessive distal renal tubular acidosis (DRTA), a substantial fraction of the patients have progressive bilateral sensorineural hearing loss. This coexistence is due to the mutations of a gene expressed both in the kidney and in the cochlea. The aim of this study was to assess the correlation between hearing loss and DRTA.

Materials and Methods. In this study, 51 children diagnosed with renal tubular acidosis were evaluated. Diagnosis of DRTA was based on clinical manifestations and detection of normal anion gap metabolic acidosis, urine pH higher than 5.5, and positive urinary anion gap. Audiometry was performed in children with DRTA and sequencing of the ATP6V1B1 gene was done for those with sensorineural hearing loss.

Results. Twenty-seven patients (52.9%) had DRTA, of whom 51.9% were younger than 1 year old, 55.6% were boys, and 44.4% were girls. Eleven patients (40.7%) had bilateral sensorineural hearing loss, consisting of 5 of 15 boys (33.3%) and 6 of 12 girls (50.0%). There was no correlation between hearing loss and gender. Three patients with hearing loss had mutation in the ATP6V1B1 gene (11.1% of patients with DRTA and 27.3% of patients with DRTA and hearing loss).

Conclusions. This study indicated that a significant percentage of the children with DRTA had sensorineural hearing loss and mutation in ATP6V1B1 gene. It is recommended to investigate hearing impairment in all children with DRTA.

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Published

2010-06-12

Issue

Section

ORIGINAL | Kidney Diseases

How to Cite

Distal Renal Tubular Acidosis and Its Relationship With Hearing Loss in Children: Preliminary Report. (2010). Iranian Journal of Kidney Diseases, 4(3), 202-206. https://ijkd.org/index.php/ijkd/article/view/188

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