Prediction of Acute Kidney Injury by Fibroblast Growth Factor 23 (FGF-23) in Adult Patients, A Meta-analysis Study

Authors

  • Wei Tao Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China Author
  • Shu-Wen Guo Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China Author
  • Yu-Jie Fan Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China Author
  • Feng Zheng Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China Author

Abstract

Introduction. The aim of the current meta-analysis was to assess the predictive value of blood fibroblast growth factor 23 (FGF-23) for acute kidney injury (AKI) in adult patients. Methods. We retrieved relative publications from electronic databases including the Cochrane Library, PubMed, Google Scholar, Scopus, web of science, and Wanfang Data from their inception to Aug 2022. Results. This meta-analysis study included seven prospective cohort trials comprising 1,655 adult patients. The overall pooled area under the receiver operating characteristic curve (AUC) from seven studies was 0.83 (95% CI: 0.80 to 0.86). Significant heterogeneity was identified (Q = 9.82, P = .004, I2 = 80). Pooled sensitivity and specificity were 0.75 (95% CI: 0.59 to 0.87) and 0.77 (95% CI: 0.65 to 0.87), respectively. Pooled positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 3.3 (95% CI: 1.8 to 6.3), 0.32 (95% CI: 0.16 to 0.63), and 10 (95% CI: 3 to 38); respectively. Moreover, our sensitivity analysis showed that when a trial from Asia was excluded, the predictive value of FGF-23 was declined. Conclusion. Our results of meta-analysis of seven prospective cohort trials suggested that blood FGF-23 is a candidate indicator for the prediction of AKI in adult patients. Results of future large and well-designed clinical trials are still needed.

 

DOI: 10.52547/ijkd.7189

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Author Biography

  • Wei Tao, Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China
    Advanced Institute for Medical Sciences dean

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Published

2023-02-01

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Section

REVIEW | Kidney Diseases

How to Cite

Prediction of Acute Kidney Injury by Fibroblast Growth Factor 23 (FGF-23) in Adult Patients, A Meta-analysis Study. (2023). Iranian Journal of Kidney Diseases, 17(1), 1-8. https://ijkd.org/index.php/ijkd/article/view/7189