The Critical Role of Therapeutic Plasma Exchange in the Treatment of MPO-ANCA Associated Crescentic IgA Nephropathy

Authors

  • Deniz Durmaz Department of Internal Medicine, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey Author
  • Buse Anbarcioglu Department of Internal Medicine, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey Author
  • Mesudiye Bulut Department of Nephrology, Gulhane Training and Research Hospital, University of Health Sciences Author
  • Bulent Erdogan Department of Nephrology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey Author
  • Ertugrul Celik Department of Pathology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey Author
  • Hadim Akoglu Department of Nephrology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey Author

Abstract

Crescentic IgA nephropathy (IgAN) with the positivity for antineutrophilic cytoplasmic antibody (ANCA) is a novel and uncommon entity. The optimal management of this condition is not well-defined. We report a 49-years-old woman with complaints of skin rash and swelling of lower limbs. She had hematuria, proteinuria and, progressive renal impairment with positive myeloperoxidase (MPO)-ANCA test. A renal biopsy revealed MPO-ANCA-associated crescentic IgAN. Induction therapy was intravenous methylprednisolone, cyclophosphamide and, therapeutic plasma exchange (TPE). An unexpected disease flare-up was observed during induction immunosuppressive therapy which regressed after long-term TPE. The patient experienced a full renal recovery after treatment with long-term TPE, cyclophosphamide, and corticosteroids.

 

DOI: 10.52547/ijkd.6490

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Author Biographies

  • Deniz Durmaz, Department of Internal Medicine, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
    Deniz Durmaz is a Medical Doctor of Internal Medicine in Gulhane Training and Research Hospital at University of Health Sciences 
  • Buse Anbarcioglu, Department of Internal Medicine, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
    Buse Anbarcioglu is a Medical Doctor of Internal Medicine in Gulhane Training and Research Hospital at University of Health Sciences
  • Mesudiye Bulut, Department of Nephrology, Gulhane Training and Research Hospital, University of Health Sciences
    Mesudiye Bulut is a Medical Doctor of Nephrology in Gulhane Training and Research Hospital at University of Health Sciences
  • Bulent Erdogan, Department of Nephrology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
    Bulent Erdogan is a Medical Doctor of Nephrology in Gulhane Training and Research Hospital at University of Health Sciences
  • Ertugrul Celik, Department of Pathology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
    Ertugrul Celik is a Medical Doctor of Pathology in Gulhane Training and Research Hospital at University of Health Sciences
  • Hadim Akoglu, Department of Nephrology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
    Hadim Akoglu is a Professor of Nephrology in Gulhane Training and Research Hospital at University of Health Sciences

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Published

2022-03-06

Issue

Vol. 16 No. 1 (2022): January

Section

CASE REPORT | Kidney Diseases

How to Cite

The Critical Role of Therapeutic Plasma Exchange in the Treatment of MPO-ANCA Associated Crescentic IgA Nephropathy. (2022). Iranian Journal of Kidney Diseases, 16(1), 63-65. https://ijkd.org/index.php/ijkd/article/view/6490

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