Angiotensin Converting Enzyme Gene Insertion/Deletion Variant and Familial Mediterranean Fever-related Amyloidosis

Authors

  • Ayse Feyda Nursal Department of Medical Genetic, Faculty of Medicine, Hitit University, Corum, Turkey Author
  • Ercan Turkmen Nephrology Clinics, Ordu State Hospital, Ordu, Turkey Author
  • Suheyla Uzun Kaya Department of Internal Medicine, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey Author
  • Akin Tekcan Department of Medical Biology, Faculty of Medicine, Ahi Evran University, Kirsehir, Turkey Author
  • Ozlem Sezer Samsun Training and Research Hospital, Genetic Clinics, Samsun, Turkey Author
  • Sumeyya Deniz Celik Department of Medical Biology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey Author
  • Serbulent Yigit Department of Medical Biology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey Author

Abstract

Introduction. The most important complication of familial Mediterranean fever (FMF) is secondary amyloidosis, which can lead to kidney failure. Genetic variability in the genes of various components of the renin-angiotensin system may play a role in the pathogenesis of the kidney disorders.  The aim of the present study was to investigate the association between angiotensin converting enzyme (ACE) gene I/D variant and risk of developing FMF-related amyloidosis in Turkish patients.

Materials and Methods. A total of 240 individuals consisting of 40 patients with FMF-related amyloidosis, 100 FMF patients without amyloidosis, and 100 healthy controls were recruited. For all of the participants, ACE I/D variant was detected by the polymerase chain reaction using specific primers.

Results. A significant difference was found between the patients with FMF-related amyloidosis and the control group as for genotype distribution of ACE I/D variant (P < .05). The ACE D/D and I/D genotypes were more frequent in the patients with FMF-related amyloidosis while the I/I genotype was less frequent in the same patients. The FMF patients (with and without amyloidosis) had significantly higher percentages of the D/D and I/D genotypes than the healthy controls (P < .05). Comparison between the subgroups of FMF patients, divided into those with and without amyloidosis, yielded a significant correlation according to ID+II versus DD genotypes (P < .03, odds ratio, 3.24; 95% confidence interval, 1.05 to 12.01). 

Conclusions. Based on these observations, the ACE I/D variant D/D genotypes implicate a possible risk in the FMF-related amyloidosis among Turkish population.

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Published

2018-06-07

Issue

Section

ORIGINAL | Kidney Diseases

How to Cite

Angiotensin Converting Enzyme Gene Insertion/Deletion Variant and Familial Mediterranean Fever-related Amyloidosis. (2018). Iranian Journal of Kidney Diseases, 12(3), 150-155. https://ijkd.org/index.php/ijkd/article/view/3598

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