Protective Effect of Quercetin Against Oxidative Stress-induced Toxicity Associated With Doxorubicin and Cyclophosphamide in Rat Kidney and Liver Tissue

Authors

  • Sayad Kocahan Department of Physiology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey; International Scientific Center, Baku State University, Baku, Azerbaijan Author
  • Zumrut Dogan Department of Anatomy, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey Author
  • Erman Erdemli Department of Biochemistry, Faculty of Medicine, Inonu University, Malatya, Turkey Author
  • Eylem Taskin Department of Physiotherapy and Rehabilitation, School of Health Sciences, Istanbul Bilim University, Istanbul, Turkey Author

Abstract

Introduction. Doxorubicin and cyclophosphamide are widely used anticancer drugs with substantial toxicity in noncancerous tissue resulting from oxidative damage. Quercetin is a potent antioxidant compound. We hypothesized that quercetin administration would ameliorate the toxic effects of doxorubicin and cyclophosphamide prior to pregnancy.

Materials and Methods. Cyclophosphamide, 27 mg/kg, and doxorubicin, 1.8 mg/kg, were administered to rats as intraperitoneal doses once every 3 weeks for a total of 10 weeks with or without concurrent treatment with quercetin, 10 mg/kg/d. Oxidative stress parameters were evaluated in maternal kidney and liver tissues after gestation.

Results. Doxorubicin was associated with elevated kidney tissue malondialdehyde relative to the controls and quercetin only treatment (P < .05). Both cyclophosphamide and doxorubicin were associated with elevated malondialdehyde levels in the liver tissue (P < .05). Doxorubicin treatment was associated with decreased liver glutathione peroxidase (P < .05). Quercetin treatment suppressed the accumulation of malondialdehyde and increased glutathione peroxidase levels during doxorubicin and cyclophosphamide treatment (P <.05)

Conclusions. Treatment with quercetin in patients receiving doxorubicin and cyclophosphamide results in therapeutic restoration of homeostatic expression of the antioxidant parameters, reducing oxidative damage to the liver and kidney.

Downloads

Download data is not yet available.

Downloads

Published

2017-02-07

Issue

Section

ORIGINAL | Kidney Diseases

How to Cite

Protective Effect of Quercetin Against Oxidative Stress-induced Toxicity Associated With Doxorubicin and Cyclophosphamide in Rat Kidney and Liver Tissue. (2017). Iranian Journal of Kidney Diseases, 11(2), 124-131. https://ijkd.org/index.php/ijkd/article/view/2860