Inflammation, Left Ventricular Hypertrophy, and Mortality in End-stage Renal Disease

Authors

  • Majlinda Cafka Service of Cardiology, University Hospital Center Mother Teresa, Tirana, Albania Author
  • Merita Rroji Service of Nephrology, University Hospital Center Mother Teresa, Tirana, Albania Author
  • Saimir Seferi Service of Nephrology, University Hospital Center Mother Teresa, Tirana, Albania Author
  • Myftar Barbullushi Service of Nephrology, University Hospital Center Mother Teresa, Tirana, Albania Author
  • Genc Burazeri Public Health Faculty, Tirana, Albania Author
  • Nereida Spahia Service of Nephrology, University Hospital Center Mother Teresa, Tirana, Albania Author
  • Alma Idrizi Service of Nephrology, University Hospital Center Mother Teresa, Tirana, Albania Author
  • Erjola Likaj Service of Nephrology, University Hospital Center Mother Teresa, Tirana, Albania Author
  • Joana Seiti Service of Cardiology, University Hospital Center Mother Teresa, Tirana, Albania Author
  • Jonida Lazaj Service of Cardiology, University Hospital Center Mother Teresa, Tirana, Albania Author
  • Artan Goda Service of Cardiology, University Hospital Center Mother Teresa, Tirana, Albania Author

Abstract

Introduction. The aim of this study was to evaluate ventricular geometry, its relationship with the inflammatory markers, and mortality of patients with end-stage renal disease on peritoneal and hemodialysis treatment.

Materials and Methods. We enrolled adult patients on long-term dialysis (hemodialysis and peritoneal dialysis) for more than 3 months. Two-dimensional echocardiography was performed by an experienced cardiologist who was blinded to all clinical details of patients. Cardiovascular mortality was assessed during a 2-year follow-up period.

Results. There were 129 participants, of whom 86 (66%) were on hemodialysis. Left ventricular hypertrophy was present in 86.7%; concentric hypertrophy was found in 64 (49.1%) and eccentric hypertrophy in 48 patients (37.2%). Patients with left ventricular hypertrophy were further divided into tertiles according to their left ventricular mass index. Logistic regression found pulse pressure as an independent risk factor associated with left ventricular mass index (odds ratio [OR], 1.04; 95% confidence interval (CI), 1.01 to 1.19; P = .047). Cardiovascular mortality rate was 15.5%. Multivariable analysis showed that C-reactive protein (OR, 1.06; 95% CI, 1.01 to 1.10; P = .01), pulse pressure (OR, 1.01; 95% CI, 1.0 to 1.26; P = .046), and left ventricular mass index (OR, 1.03; 95% CI, 1.01 to 1.21; P = .03) were independent risk factors for cardiovascular mortality.

Conclusions. Concentric hypertrophy is the most frequent left ventricular geometry model in patients with chronic kidney disease. Inflammation, pulse pressure, and  left ventricular hypertrophy are interrelated and all contribute to mortality and cardiovascular death risk among dialysis patients.

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Author Biographies

  • Majlinda Cafka, Service of Cardiology, University Hospital Center Mother Teresa, Tirana, Albania
    University Hospital Center " Mother Teresa",Deaprtment of Cardiology
  • Merita Rroji, Service of Nephrology, University Hospital Center Mother Teresa, Tirana, Albania
    University Hospital Center " Mother Theresa", Department of Nephrology.
  • Saimir Seferi, Service of Nephrology, University Hospital Center Mother Teresa, Tirana, Albania

    University Hospital Center" Mother Teresa"

    Department of Nephrology

  • Genc Burazeri, Public Health Faculty, Tirana, Albania
    Public Health Faculty.
  • Nereida Spahia, Service of Nephrology, University Hospital Center Mother Teresa, Tirana, Albania

    University Hospital Center" Mother Teresa",

    Department of Nephrology

  • Alma Idrizi, Service of Nephrology, University Hospital Center Mother Teresa, Tirana, Albania

    University Hospital Center" Mother Teresa",

    Department of Nephrology

  • Erjola Likaj, Service of Nephrology, University Hospital Center Mother Teresa, Tirana, Albania

    University Hospital Center" Mother Teresa",

    Department of Nephrology

  • Joana Seiti, Service of Cardiology, University Hospital Center Mother Teresa, Tirana, Albania

    University Hospital Center" Mother Teresa",

    Department of Cardiology

  • Jonida Lazaj, Service of Cardiology, University Hospital Center Mother Teresa, Tirana, Albania

    University Hospital Center" Mother Teresa",

    Department of Cardiology

  • Artan Goda, Service of Cardiology, University Hospital Center Mother Teresa, Tirana, Albania

    University Hospital Center" Mother Teresa",

    Department of Cardiology

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Published

2016-08-11

Issue

Section

ORIGINAL | Dialysis

How to Cite

Inflammation, Left Ventricular Hypertrophy, and Mortality in End-stage Renal Disease. (2016). Iranian Journal of Kidney Diseases, 10(4), 217-223. https://ijkd.org/index.php/ijkd/article/view/2560