The Trend of Mortality Rate and Years of Life Lost Due to Kidney Failure in Fars Province, Iran, During the Years 2004-2019
DOI:
https://doi.org/10.61882/k4badb64Abstract
Introduction. Chronic kidney disease is a general term for heterogeneous disorders that affect the structure and function of the kidney. This study was conducted to determine the mortality rate and years of life lost due to kidney failure in southern Iran. Method. In this retrospective, population-based descriptive trend study, all deaths due to kidney failure in Fars province were extracted from the electronic population-based death registration system (EDRS). The crude mortality rate, age-standardized mortality rate, years of life lost (YLL) and YLL rate data were calculated. The Joinpoint Regression method was used to examine the trend. Results. During the 16-year study period, 2853 deaths due to kidney failure occurred in Fars province. Of this number, 57.2% (1633 cases) were men. The crude mortality rate had a stable trend in men and an increasing trend in women. However, the age-standardized mortality rate had a stable trend in both sexes. The total years of life lost due to kidney failure were 19366 in men and 15769 in women. According to the Joinpoint regression analysis, the trend of YLL rate due to premature mortality was stable and the annual percent change (APC) were -2.6% (95% CI -5.6 to 0.4, P = .088) and 1.8% (95% CI -1.9 to 5.6, P = .318) for males and females respectively.
Conclusions. The trend of crude mortality rate had a stable trend in men and an increasing trend in women. Also, the trend of YLL was stable for both sexes. The increasing trend in mortality among women may be due to increases in life expectancy and the increasing prevalence of non-communicable diseases such as hypertension and diabetes mellitus.
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References
1. Levey AS, Coresh JJTl. Chronic kidney disease. 2012;379(9811):165-80. doi: 10.1016/S0140-
6736(11)60178-5.
2. Ortiz A, Covic A, Fliser D, Fouque D, Goldsmith D, Kanbay M, et al. Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure. 2014;383(9931):1831-43. doi: 10.1016/S0140-
6736(14)60384-6.
3. Eknoyan G, Lameire N, Barsoum R, Eckardt K-U, Levin A, Levin N, et al. The burden of kidney disease: improving global outcomes. 2004;66(4):1310-4. doi: 10.1111/j.1523-1755.2004.00894.x.
4. Remuzzi G, Benigni A, Finkelstein FO, Grunfeld J-P, Joly D, Katz I, et al. Kidney failure: aims for the next 10 years and barriers to success. 2013;382(9889):353-62. doi: 10.1016/S0140-6736(13)60438-9.
5. Tabrizi R, Zolala F, Nasirian M, Baneshi MR, Etminan A, Sekhavati E, et al. Estimation of the prevalence of chronic kidney disease: The results of a model based estimation in Kerman, Iran. 2016;30:338.
6. Rivara MB, Chen CH, Nair A, Cobb D, Himmelfarb J,Mehrotra RJAJoKD. Indication for dialysis initiation and mortality in patients with chronic kidney failure: a retrospective cohort study. 2017;69(1):41-50. doi: 10.1053/j.ajkd.2016.06.024.
7. Hosseinpanah F, Kasraei F, Nassiri AA, Azizi FJBpH. High prevalence of chronic kidney disease in Iran: a large population-based study. 2009;9(1):1-8. doi: 10.1186/1471-2458-9-44.
8. Shahdadi H, Sheyback M, Rafiemanesh H, Balouchi
A, Bouya S, Mahmoudirad GJAogh. Causes of chronic kidney disease in Iranian children: a meta-analysis and systematic review. 2019;85(1). doi: 10.5334/aogh.2391.
9. Malekmakan L, Malekmakan A, Daneshian A, Pakfetrat M, Roosbeh JJSJoKD, Transplantation. Hypertension and diabetes remain the main causes of chronic renal failure in Fars Province, Iran 2013. 2016;27(2). doi: 10.4103/1319-2442.178594.
10. Paciej-Gołębiowska P, Pikala MJIjoer, health p.
Twenty-Year Mortality Trends in Patients with Kidney Disease in Poland with the Use of the Years of Life Lost Measure, 2000–2019. 2022;19(5):2649. doi: 10.3390/ijerph20075355.
11. Rad EH, Kouchakinezhad-Eramsadati L, Mohtsham-Amiri Z, Davoudi-Kiakalayeh A, Yousefzadeh-Chabok SJB. Effectiveness of an educational program on decreasing burns and injuries in Persian festival of fire: a burden of diseases approach. 2019;45(2):466-70. doi: 10.1016/j. burns.2018.07.011.
12. Tohidi M, Hasheminia M, Mohebi R, Khalili D, Hosseinpanah F, Yazdani B, et al. Incidence of chronic kidney disease and its risk factors, results of over 10 year follow up in an Iranian cohort. 2012. doi: 10.1371/journal. pone.0045304.
13. Mirahmadizadeh A, Vali M, Hassanzadeh J, Dehghani SP, Razeghi A, Azarbakhsh HJIJoH. Mortality Rate and Years of Life Lost due to Hypertension in the South of Iran between 2004 and 2019: A Population-Based Study. 2022;2022. doi: 10.1155/2022/7759699.
14. Sankoh O, Sharrow D, Herbst K, Kabudula C, Alam N, Kant S. The INDEPTH standard population for low-and middle-income countries, 2013. Glob Health Action 2014; 7: 23286. doi: 10.3402/gha.v7.23286.
15. Mirahmadizadeh A, Rezaei F, Moftakhar L, Heiran N, Azarbakhsh HJAoIm. Years of Life Lost due to Suicide
in Southern Iran 2011–18: A Population–Based Study. 2022;25(1):12-6. doi: 10.34172/aim.2022.03.
16. Wang H, Abbas KM, Abbasifard M, Abbasi-Kangevari
M, Abbastabar H, Abd-Allah F, et al. Global age-sex-specific fertility, mortality, healthy life expectancy
(HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019. 2020;396(10258):1160-203. doi: 10.1016/S0140-
6736(20)30977-6.
17. Wen H, Yang D, Xie C, Shi F, Liu Y, Zhang J, et al. Comparison of trend in chronic kidney disease burden between China, Japan, the United Kingdom, and the United States. 2022;10. doi: 10.3389/fpubh.2022.999848.
18. Australian Institute of Health and Welfare (2023) Chronic kidney disease: Australian facts, AIHW, Australian Government, accessed 09 February 2023.
19. Li Y, Ning Y, Shen B, Shi Y, Song N, Fang Y, et al. Temporal trends in prevalence and mortality for
chronic kidney disease in China from 1990 to 2019: an analysis of the Global Burden of Disease Study 2019. 2023;16(2):312-21. doi: 10.1093/ckj/sfac218.
20. Takamatsu N, Abe H, Tominaga T, Nakahara K, Ito Y, Okumoto Y, et al. Risk factors for chronic kidney disease in Japan: a community-based study. 2009;10:1-10. doi: 10.1186/1471-2369-10-34.
21. Sharafi M, Eftekhari MH, Mohsenpour MA, Afrashteh
S, Baeradeh N, Fararouei M, et al. Progression of prediabetes to diabetes and its associated factors: The Fasa Adult Cohort Study (FACS). 2023:1-8. doi: 10.1007/s13410-023-01172-w
22. Hazar N, Jokar M, Namavari N, Hosseini S, Rahmanian
V. An updated systematic review and Meta-analysis of the prevalence of type 2 diabetes in Iran, 1996-2023. Front Public Health. 2024;12:1322072. doi: 10.3389/fpubh.2024.1322072.
23. Rezaianzadeh A, Johari MG, Baeradeh N, Seif M, Hosseini SV. Sex differences in hypertension incidence and risk factors: a population-based cohort study in Southern Iran. BMC Public Health. 2024;24(1):3575. doi: 10.1186/s12889-024-21082-8.
24. Dehghani A, Alishavandi S, Nourimajalan N, Fallahzadeh H, Rahmanian V. Prevalence of chronic kidney diseases and its determinants among Iranian adults: results of the first phase of Shahedieh cohort study. BMC nephrology. 2022;23(1):203. doi: 10.1186/s12882-022-02832-5.
25. Kabootari M, Habibi Tirtashi R, Amouzegar A, Masoumi S, Azizi F, Amouzegar A. Changes in metabolic syndrome status and risk of chronic kidney disease over a decade of follow-up in the Iranian population. Scientific Reports. 2025;15(1):1-8. doi: 10.1038/s41598-025-03690-5.
26. GBD Results Tool. Available online: http://ghdx.healthdata. org/gbd-results-tool (accessed on 24 January 2022).
27. Ke C, Liang J, Liu M, Liu S, Wang CJBn. Burden of chronic kidney disease and its risk-attributable burden
in 137 low-and middle-income countries, 1990–2019: results from the global burden of disease study 2019. 2022;23(1):1-12. doi: 10.1186/s12882-022-02686-x.
28. Abubakar I, Tillmann T, Banerjee AJL. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013:
a systematic analysis for the Global Burden of Disease Study 2013. 2015;385(9963):117-71. doi: 10.1016/S0140-6736(14)61682-2.
29. Jager KJ, Fraser SDJNDT. The ascending rank of chronic kidney disease in the global burden of disease study. 2017;32(suppl_2):ii121-ii8. doi: 10.1093/ndt/gfw330.
30. Nanda M, Sharma R, Jani CJN. The burden of chronic kidney disease in Asia, 1990–2019: Examination of estimates from global burden of disease 2019 study. 2022;27(7):610-20. doi: 10.1111/nep.14051.
31. De La Mata NL, Rosales B, MacLeod G, Kelly PJ, Masson P, Morton RL, et al. Sex differences in mortality among binational cohort of people with chronic kidney disease: Population based data linkage study. 2021;375. doi: 10.1136/BMJ-2021-068247.
32. The National Institute of Diabetes and Digestive and Kidney Diseases. The United States Renal Data System 2021. Available online at: https://www.usrds.org/ (accessed April 3, 2022).
33. Melquid El Nahas A, Bello AJL. Chronic kidney disease: the global challenge. 2005;365:331-40. doi: 10.1016/S0140-6736(05)17789-7.
34. Kovesdy CPJKIS. Epidemiology of chronic kidney disease: an update 2022. 2022;12(1):7-11. doi: 10.1016/j. kisu.2021.11.003.
35. Halimi L, Haghdoost AA, Alizadeh SMJMjotIRoI. Prevalence of cigarette smoking among Iranian women: a systematic review and meta-analysis. 2013;27(3):132.
36. Atlas of risk factors of non-communicable diseases in Iran (year 1400), available: https://nih.tums.ac.ir/UpFiles/Documents/3bc71b22-a5dc-4849-9d07-beede6b045e1. pdf.
37. Shankar A, Klein R, Klein BEJAjoe. The association among smoking, heavy drinking, and chronic kidney disease. 2006;164(3):263-71. doi: 10.1093/aje/kwj173.
38. Yacoub R, Habib H, Lahdo A, Al Ali R, Varjabedian L, Atalla G, et al. Association between smoking and chronic kidney disease: a case control study. 2010;10(1):1-6. doi: 10.1186/1471-2458-10-731.
39. Choi HS, Han K-D, Oh TR, Kim CS, Bae EH, Ma SK, et al. Smoking and risk of incident end-stage kidney disease in general population: a nationwide population-based cohort study from Korea. 2019;9(1):19511. doi: 10.1038/s41598-
019-56113-7.