Correlation Between the 8-hydroxy-2’-deoxyguanosine Level in the Peritoneal Solution of Patients Undergoing Peritoneal Dialysis and the Peritoneal Equilibration Test, Kt/V, Ferritin, and Albumin Levels

Abstract

Introduction. Peritoneal dialysis (PD) is an effective treatment 
modality for advanced kidney failure, offering patients a significant 
degree of independence. However, the long-term use of PD is 
limited due to the degeneration of the peritoneal membrane, 
resulting in reduced dialysis adequacy. Evaluating the peritoneal 
membrane condition in patients with advanced kidney failure 
who are undergoing PD is challenging with existing methods. 
Therefore, this study aimed to investigate the correlation between 
8-hydroxy-2’-deoxyguanosine (8OHDG) levels in the peritoneal 
solution of patients undergoing PD and various factors, such 
as peritoneal equilibration test (PET), dialysis adequacy (Kt/V), 
underlying diseases, serum ferritin, and albumin levels. 8OHDG 
is a sensitive marker of oxidative stress caused by DNA damage.
Methods. A total of 56 patients were included in this cross-sectional 
study. Five milliliters of PD fluid were collected from the patients, 
and 8-OHdG levels were measured using ELISA method. Then, they 
were compared with PET, Kt/V, albumin, and ferritin markers in 
the patients’ files, and the results were analyzed by statistical tests.
Results. The study examined the correlation between 8OHDG 
and other markers. It was found that this index had significant 
associations with PET and underlying HTN (P < .05), whereas no 
significant associations were identified with the other markers.
Conclusion. The results of the present study demonstrate that 
the level of 8OHDG, as one of the oxidative stress markers, could 
be used to evaluate the function of the peritoneum in patients 
undergoing PD.

DOI: 10.52547/ijkd.7654