Validation of Oxford Classification of Immunoglobulin A Nephropathy: an Iranian Experience

Authors

  • Alireza Sadeghipour Department of Pathology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Author
  • Alireza Hendi Department of Pathology, Golestan University, Gorgan, Iran Author
  • Mojgan Asgari Department of Pathology Hasheminejad Nejad hospital, Iran University of Medical Sciences, Tehran, Iran Author
  • Masoud Sotoudeh Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Author
  • Mahmoud Parvin Department of Pathology, Labbafi-Nejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Author
  • Irina Filip Kaiser Permanente, Fontana, California, USA Author
  • Amir Radfar AT Still University, Mesa, Arizona, USA Author
  • Pegah Babaheidarian Department of Pathology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Author

Abstract

Introduction. In 2009, the Oxford classification of immunoglobulin A (IgA) nephropathy was proposed by the working group of the International IgA Nephropathy Network and Renal Pathology Society. It established specific pathologic features that predict the risk of progression of disease. This study aimed to evaluate the interobserver reproducibility of the Oxford classification of IgA nephropathy between Iranian nephropathologists.

Materials and Methods. We included 100 patients with primary IgA nephropathy diagnosed between 2001 and 2011. Histologic slides were circulated among 4 pathologists. A score sheet was answered by each individual pathologist for each biopsy, according to the instruction of the Oxford classification. Reproducibility was determined for each variable, using intraclass correlation coefficient (ICC).

Results. The ICC values calculated for each major category of the Oxford classification were as follows: the highest score of 0.94 for tubular atrophy and interstitial fibrosis; 0.8 for glomerular basement membrane duplication, extracapillary proliferation, and segmental endocapillary proliferation; and 0.1 to 0.3 for arterial lesions, especially for hyalinosis of arterioles and intimal thickening of arcuate vessels and interlobar arteries.

Conclusions. The Oxford classification of IgA nephropathy is a useful tool and evidenced-based method with high interobserver reproducibility in pathology reporting. Our data suggest that Oxford classification may be used as a model for classification of other renal pathologies in the future.

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Author Biographies

  • Alireza Sadeghipour, Department of Pathology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
    DEPARTMENT OF PATHOLOGY
  • Alireza Hendi, Department of Pathology, Golestan University, Gorgan, Iran
    department of pathology
  • Mojgan Asgari, Department of Pathology Hasheminejad Nejad hospital, Iran University of Medical Sciences, Tehran, Iran
    department of pathology
  • Masoud Sotoudeh, Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    department of pathology
  • Mahmoud Parvin, Department of Pathology, Labbafi-Nejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    DEPARTMENT OF PATHOLOGY
  • Amir Radfar, AT Still University, Mesa, Arizona, USA
    at sil university
  • Pegah Babaheidarian, Department of Pathology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
    DEPARTMENT OF PATHOLOGY

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Published

2016-01-29

Issue

Section

ORIGINAL | Kidney Diseases

How to Cite

Validation of Oxford Classification of Immunoglobulin A Nephropathy: an Iranian Experience. (2016). Iranian Journal of Kidney Diseases, 10(1), 17-21. https://ijkd.org/index.php/ijkd/article/view/2221