A Case Report and Literature Review of Renal Calculi Accompanied by Primary Renal Pelvis Adenocarcinoma
DOI:
https://doi.org/10.52547/9knnhx91Keywords:
Renal Calculi; , Renal Pelvis Adenocarcinoma; , ChemotherapyAbstract
Introduction: In this study, we present a retrospective analysis of a complex clinical case involving a patient with concurrent renal calculi and primary renal pelvis adenocarcinoma. The case, treated at the First People's Hospital of Jiujiang, prompted an extensive literature review, aimed at enhancing the level of clinical diagnosis and treatment. The patient was a 59-year-old male who underwent urogenital ultrasound and related CT scans upon admission. The initial diagnosis was considered to be right renal calculi concomitant with a renal pelvis tumor. Subsequently, the patient underwent cystoscopy, laparoscopic right ureterectomy, and local lymph node dissection. Pathological assessments revealed primary adenocarcinoma originating from the renal pelvis urothelium. Consequently, a cisplatin-gemcitabine treatment regimen was administered. During treatment, the patient experienced renal failure, which was ineffective with ureteral catheter drainage. Unfortunately, the patient died of disease a mere three months after the discovery of renal pelvis adenocarcinoma. The coexistence of renal calculi and renal pelvis adenocarcinoma is a rare clinical disease with high malignancy and poor prognosis. In the diagnosis and treatment of urogenital calculi, the possibility of concomitant renal pelvis tumors should be considered. Moreover, early diagnosis and an aggressive treatment, including postoperative adjuvant chemotherapy and radiotherapy, may achieve better treatment effects in similar clinical contexts.
Keywords: Renal Calculi; Renal Pelvis Adenocarcinoma; Chemotherapy
Downloads
References
P G, D A, S S, et al. Mucinous adenocarcinoma of renal pelvis in a young male: a diagnostic challenge.[J]. German medical science : GMS e-journal,2020,18:c11.
Cai Xingyun, Huang Jiwei, Wang Yueming, et al. Diagnosis and treatment of primary upper urinary tract adenocarcinoma[J]. Chinese Journal of Urology.2020(05):352-355..
van de Pol JAA, van den Brandt PA, Lj S. Kidney stones and the risk of renal cell carcinoma and upper tract urothelial carcinoma: the Netherlands Cohort Study.[J]. British journal of cancer,2019,120(3):368-374.
M T, M K, Y T, et al. A surgical case of high-grade urothelial carcinoma of the renal pelvis complicated with giant hydronephrosis, giving rise to diagnostic difficulties on a cytological examination.[J]. Diagnostic pathology,2022,17(1):47.
Ej M, Jt M, G L, et al. Discordance between Ureteroscopic Biopsy and Final Pathology for Upper Tract Urothelial Carcinoma.[J]. The Journal of urology,2018,199(6):1440-1445.
Zhang Hao, Zhang Yan, Si Tujie, et al. A case report of percutaneous nephroscopic resection of a solitary renal pelvis tumor followed by infusion chemotherapy[J]. Chinese Journal of Endoscopic Urology (Electronic Edition),2013,7(2).
B F, M A, Sf M, et al. Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.[J]. European urology,2021,80(4):507-515.
Jj L, Yl C, Sl C, et al. Neoadjuvant and Adjuvant Chemotherapy for Upper Tract Urothelial Carcinoma: A 2020 Systematic Review and Meta-analysis, and Future Perspectives on Systemic Therapy.[J]. European urology,2021,79(5):635-654.
Jj L, W M, Ap F, et al. A systematic review and meta-analysis of adjuvant and neoadjuvant chemotherapy for upper tract urothelial carcinoma.[J]. European urology,2014,66(3):529-541.
A A, J G, A S. Levelling the Evidence: A Comparison of Neoadjuvant and Adjuvant Treatment for Upper Tract Urothelial Carcinoma.[J]. European urology,2021,79(5):655-656.
J H, R S, Z C, et al. The efficacy and safety of first-line treatment in cisplatin-ineligible advanced upper tract urothelial carcinoma patients: a comparison of PD-1 inhibitor and carboplatin plus gemcitabine chemotherapy.[J]. Oncoimmunology,2022,11(1):2124691.
V V, T K, Sc S, et al. Radiotherapy in Metastatic Urothelial Carcinoma: Rationale and Clinical Applications.[J]. Anticancer research,2022,42(8):3767-3778.
M K, Jk K, J L, et al. Adjuvant Treatments for Advanced Stage, Non-metastatic Upper Tract Urothelial Carcinoma: A Multicenter Study.[J]. International journal of radiation oncology, biology, physics,2019,104(4):819-827.
Je B, Ga B, P T, et al. Upper urinary tract tumors with nontransitional histology: a single-center experience.[J]. Urology,2006,67(3):518-523.
Sf M, Jp S, Pn E, et al. Patterns of Lymphatic Metastases in Upper Tract Urothelial Carcinoma and Proposed Dissection Templates.[J]. The Journal of urology,2015,194(6):1567-1574.
Downloads
Published
Data Availability Statement
no