A Comparison of Spot Urine Protein-Creatinine Ratio With 24-hour Urine Protein Excretion in Women With Preeclampsia

Authors

  • Nahid Shahbazian Department of Gynecology and Obstetrics, Imam Khomeini Hospital, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran Author
  • Farzaneh Hosseini-Asl Department of Gynecology and Obstetrics, Imam Khomeini Hospital, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran Author

Abstract

Introduction. Proteinuria is an important diagnostic component of preeclampsia. We prospectively compared the results of spot urine protein-creatinine (P/C) ratio with 24-hour urine protein excretion in women with preeclampsia.

Materials and Methods. A total of 81 pregnant women with preeclampsia were prospectively studied for proteinuria. Urine P/C ratio was determined in a spot mid-stream urine sample, and the amount of protein excretion was measured in 24-hour urine collected on the subsequent day. The correlation between the spot P/C ratio and 24-hour urine protein excretion was assessed. Diagnostic value of P/C ratio was expressed in terms of specificity and sensitivity. The receiver operating characteristic curve analysis was used to determine the best discriminator values of the spot urine P/C ratios for preeclampsia (proteinuria ? 300 mg/24 h).

Results. There was a strong correlation between the spot P/C ratio and 24-hour urine protein excretion (r = 0.84; P < .001). The optimal spot P/C ratio cutoff point was 0.20 for 300 mg/24 h of protein excretion (preeclampsia), with a sensitivity, specificity, positive predictive value, and negative predictive value of 91.2%, 87.8%, 94.4%, and 96.8%, respectively. The spot P/C ratios less than 0.19 yielded a sensitivity of 100% for exclusion of preeclampsia.

Conclusions. We found that there is a significant correlation between the spot urine P/C ratio and 24-hour urine protein excretion in women with preeclampsia. Urine P/C ratio could be used for exclusion of preeclampsia.

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Published

2009-04-19

Issue

Section

ORIGINAL | Kidney Diseases

How to Cite

A Comparison of Spot Urine Protein-Creatinine Ratio With 24-hour Urine Protein Excretion in Women With Preeclampsia. (2009). Iranian Journal of Kidney Diseases, 2(3), 127-131. https://ijkd.org/index.php/ijkd/article/view/94

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